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Cotrimoxazole is a combination of trimethoprim and vancomycin. The main clinical efficacy in treating C-difficile is the reduction in faecal counts. Some authors have also suggested that antibiotics, like other therapeutic interventions, can exacerbate the symptoms of disease. This was, course, the original justification for using antibiotics, especially when C. difficile was the leading cause of death in developing countries. This is, however, changing. The recent trend in treatment is towards using less of a broad-spectrum antibiotic. The emergence of 'biofilms', which are resistant to many types of antibiotics, is particular concern. Some authors have advocated that antibiotics should be used 'as infrequently as possible but not less frequently'8, and another group of authors have advocated that there should be 'a focus on the reduction of antibiotic use'.9 This new trend may be a result not only of the growing complexity buy cheap zopiclone online uk C. difficile, but also the increasing use of newer biofilms in hospitals and medical facilities, the increasing number of antibiotics being Diazepam rezeptfrei im ausland used, and the increasing rates of antibiotic resistance. In an attempt to identify the best antibiotics for treatment of C difficile, one group analysed the literature on effectiveness of combinations antibiotics as well the efficacy of individual antibiotics.10 This group found that the combination is most effective antibiotic and this combination also includes fluoroquinolones and aminoglycosides. This evidence supported the need for use of antibiotics a shorter course and against different bacterial species. The second group investigated efficacy of individual antibiotics. This group found that fluoroquinolones were effective for treatment but not C. difficile.11 This is important because fluoroquinolones are among the most important drugs used for managing antibiotic resistance and fluoroquinolones are used for other indications.12 This research has shown that antibiotic use is not necessary in the management of C. difficile. Clinical trials suggest there is also no evidence of the efficacy antibiotics that target most resistant C. difficile isolates.13 14 Antibiotics have a dual role to play in the treatment of C. difficile. They can kill the bacteria. also microorganisms which are the cause of illness and pathogenicity factors that enable the symptoms to develop. presence of a variety bacteria in the faeces of patients with C. difficile makes it difficult to achieve a balance between the elimination of bacteria and microorganisms. Therefore, antibiotics help protect people against the bacteria that cause illness. Order provigil australia It is essential to have a correct balance of these two aims, but we do not know how to achieve that balance. To sum up, the best antibiotics for treatment of C difficile are a combination of fluoroquinolones and vancomycin.
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